South African court refuses Zuma appeal request in arms case
In April, the court said a 2009 decision to drop the 783 charges against Mr Zuma was irrational.
He has always denied taking bribes over the arms deal.
National director of public prosecutions Shaun Abrahams had asked the court for permission to appeal against the earlier ruling, saying prosecutors should be able to exercise discretion over whether an investigation should continue.
Rejecting the request, High Court Judge Aubrey Ledwaba said: "We seriously considered whether the appeal would have reasonable prospects of success and came to the conclusion that there are no merits in the arguments."
The ruling is a blow to Mr Zuma's efforts to avoid standing trial, reports the BBC's Milton Nkosi from Johannesburg.
The president can still take the case to the Supreme Court of Appeal but it is difficult to see it overturning the unanimous ruling of the High Court, our correspondent says.
Mr Zuma's final option would be to ask the Constitutional Court to throw out the case.
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